11-Desoxycortisol (LDCOR)

EPIC Test Name

11-DESOXYCORTISOL

EPIC Code

LAB975

Reference Lab

This test is performed by a partner lab as indicated below.

Lab	Referral
Core Lab Sendouts - Downtown	Click Here to visit LabCorp

Special Instructions

No isotopes administered 24 hours prior to venipuncture.

Clinical Indications

Evaluate hypothalamic-pituitary-adrenal axis and pituitary ACTH reserve.

Additional Information

11-Deoxycortisol is the immediate precursor of cortisol and follows the same catabolic pathways as cortisol. The conversion of 11-deoxycortisol to cortisol is inhibited by metyrapone, which acts on 11-β-hydroxylase. The metyrapone test (see the online Endocrine Appendix: ACTH Stimulation) serves as a reliable and sensitive indicator of pituitary ACTH secretory reserve. The 11-deoxycortisol levels normally increase to 100 times the control value following metyrapone administration. Reduced response occurs in patients with hypoadrenalism or with hypopituitarism and in some patients with diseases of the hypothalamus. Patients with myxedema, some pregnant patients, and those on oral contraceptives respond poorly.

Common Synonyms

Compound S for Metyrapone Test, RL 500550

CPT

82634

LOINC

1657-6

References

Sindler BH, Griffing GT, Melby JC, et al. The superiority of the metyrapone test versus the high-dose dexamethasone test in the differential diagnosis of Cushing's syndrome. Am J Med. 1983 Apr; 74(4):657-662. PubMed 6837591

Spark RF. Simplified assessment of pituitary-adrenal reserve: Measurement of serum 11-deoxycortisol after metyrapone. Ann Intern Med. 1971 Nov; 75(5):717-723. PubMed 4330677

Contact Information

Core Lab Sendouts - Downtown: (315)464-6818